Karen L. Wooley

W.T. Doherty-Welch Foundation Chair in Chemistry

Professor - Chemistry

Contact Information

Phone: (979) 845-4077

Fax: (979) 862-1137

E-mail: wooley@mail.chem.tamu.edu

Departmental Page


  • Ph. D. 1993, Cornell University, Polymer/Organic Chemistry, August
  • B.S. 1988, Chemistry, Oregon State University

Research Interests

Organic and polymer synthesis; novel macromolecular nanostructures for biomedical and materials applications; degradable polymers; nanoscale polymer assemblies; functional polymers; polymer modification.


2009 - Present

  • W. T. Doherty-Welch Chair in Chemistry; Professor of Chemistry; Professor of Chemical Engineering, Texas A&M University

2007 - 2009

  • Professor, Washington University, School of Medicine, Department of Radiology


  • James S. McDonnell Distinguished University Professor of Arts & Sciences


  • Professor, Washington University, School of Arts & Sciences, Department of Chemistry

1996 - 2005

  • Faculty member in the Division of Biological and Biomedical Sciences, Chemical Biology Program, Washington University

1993 - 1999

  • Assistant Professor, Department of Chemistry, Washington University


  • Brush Copolymers", Cheng, Chong; Khoshdel, Ezat; Wooley, Karen L.; Patent WO 2008/064972, US Patent 7,960,479 issued June 14, 2011.
  • "Functionalized, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy", Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; Appl. Serial Number 61/334,698; PCT Int. Appl. US11/36392; Filed May 15, 2011.
  • "Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH", Wooley, Karen L.; Dorshow, Richard B.; Freskos, John N.; Neumann, William L.; Shieh, Jeng J.; Lee, Nam S.; Lin, Yun; Sun, Guorong; Appl. Serial Number 61/334,723; PCT Int. Appl. US11/36411; Filed May 13, 2011.
  • "Degradable Polycarbonates From Polyhydroxy Natural Products", Wooley, Karen L; Besset, Celine J.; Lonnecker, Alexander T; Streff, Jennifer M.; Kristufek, Samantha L.; Hearon, Michael K.; Provisional; Appl. Serial Number 61/392,893; PCT/US2011/56204; Filed October 13, 2010.
  • "Composition Comprising Brush Copolymer For Treating Hair", Burry, Jason Shaun; Cheng, Chong; Evans, Richard Livesey; Khoshdel, Ezat; Wooley, Karen Lynn; Patent WO 2008/064973; granted August 2010.


In press—

  • He, X.; Fan, J.; Wooley, K. L. “Stimuli-triggered Sol-Gel Transitions of Polypeptide Gels Derived from N-carboxyanhydride (NCA) Polymerizations”, Chem. Asian J., in press.
  • Zigmond, J. S.; Pollack, K. A.; Smedley, S.; Raymond, J. E.; Link, L. A.; Pavia-Sanders, A.; Hickner, M. A.; Wooley, K. L. “Investigation of Intricate, Amphiphilic Crosslinked Hyperbranched Fluoropolymers as Anti-icing Coatings for Extreme Environments”, J. Polym. Sci., Part A:  Polym. Chem., Early View, DOI: 10.1002/pola.27800.

Published— 10 most recent

  • Yang, F.; Cho, S.; Sun, G.; Verkhoturov, S. V.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L.; Schweikert, E. A. “Nanodomain Analysis with Cluster-SIMS: Application to the characterization of macromolecular brush architecture”, Surface and Interface Analysis, 2015, 47(11), 1051-1055, DOI: 10.1002/sia.5812.
  • Elsabahy, M.; Heo, G. S.; Lim, S.-M.; Sun, G.; Wooley, K. L. “Polymeric Nanostructures for Imaging and Therapy”, Chem. Rev., 2015, 115, 10967-11011, DOI: 10.1021/acs.chemrev.5b00135.
  • Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48(16), 5621-5631, DOI: 10.1021/acs.macromol.5b00752.
  • Wagers, P. O.; Tiemann, K. M.; Shelton, K. L.; Kofron, W. G.; Panzner, M. J.; Wooley, K. L.; Youngs, W. J.; Hunstad, D. A. “Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model”, Antimicrobial Agents and Chemotherapy, 2015, 59(9), 5494-5502, DOI: 10.1128/AAC.00881-15.
  • Weems, A. C.; Raymond, J. E.; Wacker, K. T.; Gustafson, T. P.; Keller, B.; Wooley, K. L.; Maitland, D. J. “Examination of radio-opacity enhancing additives in shape memory polyurethane foams”, J. Appl. Polym. Sci., 2015, 132(33), 42054 (9 pp), DOI: 10.1002/app.42054.
  • Hearon, K.; Wierzbicki, M. A.; Nash, L. D.; Landsman, T. L.; Laramy, C.; Lonnecker, A. T.; Gibbons, M. C.; Ur, S.; Cardinal, K. O.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Processable Shape Memory Polymer System for Biomedical Applications”, Adv. Healthcare Mater., 2015, 4, 1386-1398, DOI: 10.1002/adhm.201500156.
  • Aweda, T. A.; Zhang, S.; Mupanomunda, C.; Burkemper, J.; Heo, G. S.; Bandara, N.; Lin, M.; Cutler, C. S.; Cannon, C. L.; Youngs, W. J.; Wooley, K. L.; Lapi, S. E. “Investigating the pharmacokinectics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer”, J. Labelled Comp. Radiopharm., 2015, 58(6), 234-241, DOI: 10.1002/jlcr.3289. PMCID: PMC4457551.
  • Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett., 2015, 4(6), 645-650, DOI: 10.1021/acsmacrolett.5b00227. PMCID:  PMC4477896.
  • Elsabahy, M.; Wooley, K. L. “Data Mining as a Guide for the Construction of Biocompatible Nanoparticles via Controlling Polymer Chemistry and Supramolecular Assembly”, Acc. Chem. Res., 2015, 48(6), 1620-1630, DOI: 10.1021/acs.accounts.5b00066. PMCID:  PMC4500541.
  • Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”, Chem. Mater., 2015, 27, 3775-3782, DOI: 10.1021/acs.chemmater.5b01523.
  • Seetho, K.; Zhang, S.; Pollack, K. A.; Zou, J.; Raymond, J. E.; Wooley, K. L. “Facile Synthesis of a Phosphorylcholine-based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings”, ACS Macro Lett., 2015, 4, 505-510, DOI: 10.1021/mz500818c.