Karen L. Wooley

University Distinguished Professor - Chemistry

W.T. Doherty-Welch Foundation Chair in Chemistry

Presidential Impact Fellow

Contact Information

Phone: (979) 845-4077

Fax: (979) 862-1137

E-mail: wooley@mail.chem.tamu.edu

Departmental Page

Experience

  • 2017 – Lifetime           Presidential Impact Fellow, Texas A&M University
  • 2014 – Present           Professor of Materials Science & Engineering , Texas A&M University
  • 2014 – Present           Professor of Biotechnology Program, Texas A&M University
  • 2011 – Present           University Distinguished Professor, Texas A&M University
  • 2009 – Present           W. T. Doherty-Welch Chair in Chemistry; Professor of Chemistry; Professor of Chemical Engineering, Texas A&M University
  • 2007 – 2009                Professor, Washington University, School of Medicine, Department of Radiology
  • 2006-2009                   James S. McDonnell Distinguished University Professor of Arts & Sciences
  • 1999-2009                   Professor, Washington University, School of Arts & Sciences, Department of Chemistry
  • 1996 – 2005                Faculty member in the Division of Biological and Biomedical Sciences, Chemical Biology Program, Washington University
  • 1993 – 1999                Assistant Professor, Department of Chemistry, Washington University

Education

  • 1993    Ph. D. Cornell University, Polymer/Organic Chemistry.
  • 1988    B.S. Chemistry, Oregon State University.

Research Interests

Organic and polymer synthesis; novel macromolecular nanostructures for biomedical and materials applications; degradable polymers; nanoscale polymer assemblies; functional polymers; polymer modification.

 

 

Patents

  • “Degradable Polycarbonate Sport Fishing Materials”, Wooley, Karen L.; Felder, Simcha E.; Versaw, Brooke A.; Jahnke, Ashlee A.; Link, Lauren A.; Wooley, Mark W.; Hinton, Charles A.; Howell, Jr., William R.; U.S. Provisional Patent Application Serial No. 62/362,885, filed July 15, 2016; U.S. Patent Application Serial No. 15/650,244, filed July 14, 2017; PCT International Application Serial No. PCT/US2017/042061, filed July 14, 2017; US Patent Application Publication No. 20180016390-A1, filed January 18, 2018.  Appl. No. EP3484942 filed May 22, 2019; U.S. Patent Number 10,329,381, issued June 25, 2019.
  • “Functional, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy”, Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; U.S. Patent Application Serial No. 13/697,149, filed November 17, 2011; WO 2011143524, filed November 17, 2011; PCT International Application Serial No. PCT/US2011/036392, filed December 13, 2012; Prior Publication Data: US 2013/0137976 A1, May 30, 2013; U.S. Patent Number 9,295,650, issued March 29, 2016;and U.S. Patent Number 9,662,387 B2, issued May 30, 2017.  
  • “Ternary Antifouling Compositions and Methods”, Wooley, Karen L.; Raymond, Jeffery E.; Pollack, Kevin A; Imbesi, Philip M; ; U.S. Patent Application Serial No. 14/575,625, filed December 18, 2014; WO 2013192529; Prior Publication Data: US 2015/0307720 A1, October 29, 2015; U.S. Patent Number 9,422,433 issued August 23, 2016.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,371, filed September 6, 2013; Prior Publication Data: US 2015/0072292 A1, March 12, 2015; U.S. Patent Number 9,405,189 issued August 2, 2016.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,343, filed September 6, 2013; Prior Publication Data: US 2015/0072291, filed March 12, 2015.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,019, filed November 19, 2012; Prior Publication Data: US 2014/0141376 A1, May 22, 2014; U.S. Patent Number 8,822,130 issued September 2, 2014.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,026, filed November 19, 2012; Prior Publication Data: US 2014/0141375 A1, May 22, 2014; U.S. Patent Number 9,223,214 issued December 29, 2015.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; Full Appl. Serial Number 13/681,012, filed November 19, 2012; Prior Publication Data: US 2014/0142252, May 22, 2014.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,002, filed November 19, 2012; Prior Publication Data: US 2014/0142249 A1, May 22, 2014; U.S. Patent Number 9,447,220 issued September 20, 2016.
  • “Polymer-Drug Systems”, Wooley, Karen L.; Zou, Jiong; El Sabahy, Mahmoud; Zhang, Shiyi; Zhang, Fuwu; U.S. Patent Number 9,545,447 issued January 17, 2017.
  • Brush Copolymers", Cheng, Chong; Khoshdel, Ezat; Wooley, Karen L.; Patent WO 2008/064972, US Patent 7,960,479 issued June 14, 2011.
  • "Functionalized, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy", Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; Appl. Serial Number 61/334,698; PCT Int. Appl. US11/36392; Filed May 15, 2011.
  • "Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH", Wooley, Karen L.; Dorshow, Richard B.; Freskos, John N.; Neumann, William L.; Shieh, Jeng J.; Lee, Nam S.; Lin, Yun; Sun, Guorong; Appl. Serial Number 61/334,723; PCT Int. Appl. US11/36411; Filed May 13, 2011.
  • "Degradable Polycarbonates From Polyhydroxy Natural Products", Wooley, Karen L; Besset, Celine J.; Lonnecker, Alexander T; Streff, Jennifer M.; Kristufek, Samantha L.; Hearon, Michael K.; Provisional; Appl. Serial Number 61/392,893; PCT/US2011/56204; Filed October 13, 2010.
  • "Composition Comprising Brush Copolymer For Treating Hair", Burry, Jason Shaun; Cheng, Chong; Evans, Richard Livesey; Khoshdel, Ezat; Wooley, Karen Lynn; Patent WO 2008/064973; granted August 2010.

Publications

Published— 

  • Liang, Z.; Nguyen, T. P.; Attanayake, N. H.; Easley, A. D.; Lutkenhaus, J. L.; Wooley, K. L.; Odom, S. A. “Metal-free Polypeptide Redox Flow Batteries”, Materials Advances, 2022, 3, 6558-6565, DOI: 10.1039/d2ma00498d.
  • Eissa, R. A.; Saafan, H. A.; Ali, A. E.; Ibrahim, K. M.; Eissa, N. G.; Hamad, M. A.; Pang, C.; Guo, H.; Gao, H.; Elsabahy, M.; Wooley, K. L. “Design of Nanoconstructs that Exhibit Enhanced Hemostatic Efficiency and Bioabsorbability”, Nanoscale, 2022, 14, 10738-10749, DOI: 10.1039/d2nr02043b.
  • Kang, N.; Cho, S.; Leonhardt, E. E.; Liu, C.; Verkhoturov, S. V.; Woodward, W. H.; Eller, M. J.; Yuan, T.; Fitzgibbons, T. C.; Borguet, Y.; Jahnke, A. A.; Sokolov, A. N.; McIntire, T.; Reinhardt, C.; Fang, L.; Schweikert, E. A.; Spencer, L. P.; Sun, G.; Trefonas, P.; Wooley, K. L. “Topological Design of Highly Anisotropic Aligned Hole Transporting Molecular Bottlebrushes for Solution-processed OLEDs”, J. Am. Chem. Soc., 2022, 144(18), 8084-8095, DOI: 10.1021/jacs.2c00420
  • Shen, Y.; Yang, X.; Song, Y.; Tran, D. K.; Wang, H.; Wilson, J.; Dong, M.; Vazquez, M.; Sun, G.; Wooley, K. L. “Complexities of Regioselective Ring-Opening vs. Transcarbonylation-Driven Structural Metamorphosis during Organocatalytic Polymerizations of Five-Membered Cyclic Carbonate Glucose Monomers”, JACS Au, 2022, 2(2), 515-521, DOI: 10.1021/jacsau.1c00545.
  • Tran, D. K.; Rashad, A. Z.; Darensbourg, D. J.; Wooley, K. L. “Sustainable Synthesis of CO2-derived polycarbonates from D-xylose”, Polym. Chem., 2021, 12, 5271-5278, DOI: 10.1039/D1PY00784J. Part of the “Sustainable Polymers online themed collection” and selected as a HOT Polymer Chemistry article.
  • Elsabahy, M.; Song, Y.; Eissa, N. G.; Khan, S.; Hamad, M. A.; Wooley, K. L. “Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides”, J. Control. Release, 2021, 334, 1-10, DOI: 10.1016/j.jconrel.2021.04.006.
  • Song, Y.; Elsabahy, M.; Collins, C. A.; Khan, S.; Li, R.; Hreha, T. N.; Shen, Y.; Lin, Y.-N.; Letteri, R. A.; Su, L.; Dong, M.; Zhang, F.; Hunstad, D. A.; Wooley, K. L. “Morphologic Design of Silver-Bearing Sugar-Based Polymer Nanoparticles for Uroepithelial Cell Binding and Antimicrobial Delivery”, Nano Lett., 2021, 21(12), 4990-4998, DOI: 10.1021/acs.nanolett.1c00776.
  • Nguyen, T. P.; Easley, A. D.; Kang, N.; Khan, S.; Lim, S.-M.; Rezenom, Y. H.; Wang, S.; Tran, D. K.; Fan, J.; Letteri, R. A.; He, X.; Su, L.; Yu, C.-H.; Lutkenhaus, J. L.; Wooley, K. L. “Polypeptide Organic Radical Batteries”, Nature, 2021, 593, 61-66, DOI: 10.1038/s41586-021-03399-1. Direct Link to: Article/Methods/Data PDF. Several Press Releases: 1) Texas A&M Researchers develop new metal-free recyclable polypeptide battery that degrades on-demand; 2) Chemical & Engineering News - Highlight (Vol. 99, Issue 17, page 7); 3) KXXV News - Segment on Polypeptide Battery featuring Dr. Jodie Lutkenhaus; 4) Nature Community blog post - The story behind the team’s paper & progress from battery concept to creation; 5) Nature Podcast - Dr. Jodie Lutkenhaus speaks on the new battery in the final eight minutes (segment begins at the 11:36 mark); 6) Futurity - Quote by Dr. Karen Wooley and The Next Step; 7) Research Highlight for Nature Reviews Materials.
  • Elsabahy, M.; Wooley, K. L.; Hendricksen, A.; Oh, K. “Multiple analyte profiling (MAP) index as a powerful diagnostic and therapeutic monitoring Tool”, Methods, 2021, 190, 26-32, DOI: 10.1016/j.ymeth.2020.03.006.
  • Pectol, D. C.; Khan, S.; Elsabahy, M.; Wooley, K. L.; Lim, S.-M.; Darensbourg, M. Y. “Effects of Glutathione and Histidine on NO Release from a Dimeric Dinitrosyl Iron Complex (DNIC)”, Inorg. Chem., 2020, 59(23), 16998-17008, DOI: 10.1021/acs.inorgchem.0c02196.
  • Song, Y.; Yang, X.; Shen, Y.; Dong, M.; Lin, Y.-N.; Hall, M. B.; Wooley, K. L. “Invoking side-chain functionality for the mediation of regioselectivity during ring-opening polymerization of glucose carbonates”, J. Am. Chem. Soc., 2020, 142(40), 16974-16981, DOI: 10.1021/jacs.0c05610.
  • Lee, J. Y.; Song, Y.; Wessels, M. G.; Jayaraman, A.; Wooley, K. L.; Pochan, D. J. "Hierarchical Selfassembly of Poly(D-glucose carbonate) Amphiphilic Block Copolymers in Mixed Solvents", Macromolecules, 2020, 53(19), 8581-8591, DOI: 10.1021/acs.macromol.0c01575.
  • Lin, Y.-N.; Khan, S.; Song, Y.; Dong, M.; Shen, Y.; Tran, D. K.; Pang, C.; Zhang, F.; Wooley, K. L. “A Tale of Drug-Carrier Optimization: Controlling stimuli sensitivity via nanoparticle hydrophobicity through drug loading”, Nano Lett., 2020, 20(9), 6563-6571, DOI: 10.1021/acs.nanolett.0c02319.
  • Lin, Y.-N.; Elsabahy, M.; Khan, S.; Zhang, F.; Song, Y.; Dong, M.; Li, R.; Smolen, J. A.; Letteri, R. A.; Su, L.; Wooley, K. L. “Erythrocyte membrane-camouflaged nanocarriers with tunable paclitaxel release kinetics via macromolecular stereocomplexation”, ACS Mater. Lett., 2020, 2(6), 595-601, DOI: 10.1021/acsmaterialslett.0c00044.
  • Dong, M.; Song, Y.; Wang, H.; Su, L.; Shen, Y.; Tran, D. K.; Letteri, R. A.; Flores, J. A.; Lin, Y.-N.; Li, J.; Wooley, K. L. “Degradable Sugar-based Magnetic Hybrid Nanoparticles for Recovery of Crude Oil from Aqueous Environments”, Polym. Chem., 2020, 11(30), 4895-4903, DOI: 10.1039/D0PY00029A. [Special Issue on the topic of “Plastics Circular Economy”]
  • Zhang, Q.; Wooley, K. L. “Investigation of Segmental Reorganization within Amphiphilic Block Polymer Nanoparticles Derived from Shell Crosslinked Micelle Templates: Shell crosslinked knedel-like inversion”, J. Polym. Sci., 2020, 58(1), 204-214, DOI: 10.1002/pol.20190089. [A special issue in tribute to Krzysztof Matyjaszewski on the occasion of his 70th birthday.]
  • Li, R.; Wang, H.; Song, Y.; Lin, Y.-N.; Dong, M.; Shen, Y.; Khan, S.; Zhang, S.; Fan, J.; Zhang, F.; Su, L.; Wooley, K. L. “In situ production of Ag/polymer asymmetric nanoparticles via a powerful light-driven technique”, J. Am. Chem. Soc., 2019, 141(50), 19542-19545, DOI: 10.1021/jacs.9b10205.
  • Heo, G. S.; Cho, S.; Wooley, K. L. “Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers”, Macromol. Res., 2019, 27(11), 1173-1178, DOI: 10.1007/s13233-020-8044-x.
  • Ron, C. A.; Dong, M.; Wooley, K. L.; Johnson, W. P. “Theory-Guided Targeted Delivery of Nanoparticles in Advective Environmental Porous Media”, Environ. Sci. Technol. Lett., 2019, 6(10), 617-623, DOI: 10.1021/acs.estlett.9b00474.
  • Beltran-Villegas, D. J.; Wessels, M. G.; Lee, J. Y.; Song, Y.; Wooley, K. L.; Pochan, D. J.; Jayaraman,  A “Computational Reverse-Engineering Analysis for Scattering Experiments on Amphiphilic Block Polymer Solutions”, J. Am. Chem. Soc., 2019, 141(37), 14916-14930, DOI: 10.1021/jacs.9b08028.
  • Heo, G. S.; Zhao, Y.; Sultan, D.; Zhang, X.; Detering, L.; Luehmann, H. P.; Zhang, X.; Li, R.; Choksi, A.; Sharp, S.; Levingston, S.; Primeau, T.; Reichert, D. E.; Sun, G.; Razani, B.; Li, S.; Weilbaecher, K. N.; Dehdashti, F.; Wooley, K. L.; Liu, Y. “Assessment of Copper Nanoclusters for Accurate In vivo Tumor Imaging and Potential for Translation”, ACS Appl. Mater. Interfaces, 2019, 11(22), 19669-19678, DOI: 10.1021/acsami.8b22752.
  • Pectol, D. C.; Chupik, R. B.; Khan, S.; Elsabahy, M.; Wooley, K. L.; Darensbourg, M. Y.; Lim, S.-M. “Toward the Optimization of Dinitrosyl Iron Complexes as Therapeutics for Smooth Muscle Cells”, Mol. Pharmaceutics, 2019, 16(7), 3178-3187, DOI: 10.1021/acs.molpharmaceut.9b00389.
  • Leonhardt, E. E.; Kang, N.; Hamad, M. A.; Wooley, K. L.; Elsabahy, M. “Absorbable Hemostatic Hydrogels Comprising Composites of Sacrificial Templates and Honeycomb-like Nanofibrous Mats of Chitosan”, Nature Commun., 2019, 10:2307, 1-9, DOI: 10.1038/s41467-019-10290-1.
  • Dong, M.; Wessels, M. G.; Lee, J. Y.; Su, L.; Wang, H.; Letteri, R. A.; Song, Y.; Lin, Y.-N.; Chen, Y.; Li, R.; Pochan, D. J.; Jayaraman, A.; Wooley, K. L. “Experiments and Simulations of Complex Sugar‑based Coil‑brush Block Polymer Nanoassemblies in Aqueous Solution”, ACS Nano, 2019, 13(5), 5147-5162, DOI: 10.1021/acsnano.8b08811.
  • Elsabahy, M.; Wooley, K. L.; Hendricksen, A.; Oh, K. “Multiplexing Techniques for Measurement of the Immunomodulatory Effects of Particulate Materials: Precautions when testing micro- and nano-particles”, Methods, 2019, 158, 81-85, DOI:  10.1016/j.ymeth.2019.01.006.
  • Li, R.; Elsabahy, M.; Song, Y.; Wang, H.; Su, L.; Letteri, R.A.; Khan, S.; Heo, G. S.; Sun, G.; Liu, Y.; Wooley, K. L. “Functional, degradable zwitterionic polyphosphoesters as biocompatible coating materials for metal nanostructures”, Langmuir, 2019, 35(5), 1503-1512, DOI: 10.1021/acs.langmuir.8b02033.  [A special issue on the topic of “Zwitterionic Interfaces:  Concepts and emerging applications”].
  • Osumi, S.; Felder, S. E.; Wang, H.; Lin, Y.-N.; Dong, M.; Wooley, K. L. “Construction of nanostructures in aqueous solution from amphiphilic glucose-derived polycarbonates”, J. Polym. Sci., Part A: Polym. Chem., 2019, 57(3), 432-440, DOI: 10.1002/pola.29229.  [A special issue in honor of Professor Mitsuo Sawamoto, in recognition of his outstanding achievements and retirement from 40 years of exceptional service to Kyoto University].
  • Wacker, K. T.; Weems, A. C.; Lim, S.-M.; Khan, S.; Felder, S. E.; Dove, A. P.; Wooley, K. L. “Harnessing the Chemical Diversity of the Natural Product Magnolol for the Synthesis of Renewable, Degradable Neolignan Thermosets with Tunable Thermomechanical Characteristics and Antioxidant Activity”, Biomacromolecules, 2019, 20(1), 109-117, DOI: 10.1021/acs.biomac.8b00771.  [A special issue in coordination with the 2018 Bordeaux Polymer Conference].
  • Song, Y.; Ji, X.; Dong, M.; Li, R.; Lin, Y.-N.; Wang, H.; Wooley, K. L. “Advancing the Development of Highly-functionalizable Glucose‑based Polycarbonates by Tuning of the Glass Transition Temperature”, J. Am. Chem. Soc., 2018, 140(47), 16053-16057, DOI: 10.1021/jacs.8b10675.
  • Lin, Y.-N.; Su, L.; Smolen, J.; Li, R.; Song, Y.; Wang, H.; Dong, M.; Wooley, K. L. “Co-assembly of sugar-based amphiphilic block polymers to achieve nanoparticles with tunable morphology, size, surface charge, and acid-responsive behavior”, Mater. Chem. Front., 2018, 2(12), 2230-2238, DOI: 10.1039/C8QM00353J.
  • Leonhardt, E. E.; Meador, M. A. B.; Wooley, K. L. “β-Cyclodextrin-derived Monolithic, Hierarchically Porous Polyimides Designed for Versatile Molecular Separation Applications”, Chem. Mater., 2018, 30(18) 6226-6230, DOI: 10.1021/acs.chemmater.8b02843.
  • Wang, H.; Dong, M.; Khan, S.; Su, L.; Li, R.; Song, Y.; Lin, Y.-N.; Kang, N.; Komatsu, C. H.; Elsabahy, M.; Wooley, K. L. “Acid-triggered polymer backbone degradation and disassembly to achieve release of camptothecin from functional polyphosphoramidate nanoparticles”, ACS Macro Lett., 2018, 7, 783-788, DOI:  10.1021/acsmacrolett.8b00377.
  • Elsabahy, M.; Wooley, K. L. “Reassessment of Nanomaterials Immunotoxicity”, Nano Today, 2018, 20, 10-12, DOI: 10.1016/j.nantod.2018.01.002.
  • Cho, S.; Heo, G. S.; Khan, S.; Huang, J.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. “A Vinyl Ether-Functional Polycarbonate as a Template for Multiple Post-polymerization Modifications”, Macromolecules, 2018, 51(9), 3233-3242, DOI: 10.1021/acs.macromol.8b00047. PMCID:  PMC6002957.
  • Shah, P. N.; Shah, K. N.; Smolen, J. A.; Tagaev, J. A.; Torrealba, J.; Zhou, L.; Zhang, S.; Zhang, F.; Wagers, P. O.; Panzner, M. J.; Youngs, W. J.; Wooley, K. L.; Cannon, C. L. “A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model”, Sci. Rep., 2018, 8, 6376, DOI: 10.1038/s41598-018-24200-w.
  • Borguet, Y. P.; Khan, S.; Noel, A.; Gunsten, S. P.; Brody, S. L.; Elsabahy, M.; Wooley, K. L. “Development of fully degradable phosphonium-functionalized amphiphilic diblock copolymers for nucleic acids delivery”, Biomacromolecules, 2018, 19 (4), 1212-1222, DOI: 10.1021/acs.biomac.8b00069. PMCID: PMC5894060.
  • Felder, S. E.; Redding, M.; Noel, A.; Grayson, S. M.; Wooley, K. L. “Organocatalyzed ROP of a Glucopyranoside Derived 5‑Membered Cyclic Carbonate”, Macromolecules, 2018, 51(5), 1787-1797, DOI: 10.1021/acs.macromol.7b01785.
  • Su, L.; Li, R.; Khan, S.; Clanton, R.; Zhang, F.; Lin, Y.-N.; Song, Y.; Wang, H.; Fan, J.; Hernandez, S.; Butters, A. S.; Akabani, G.; MacLoughlin, R.; Smolen, J.; Wooley, K. L. “Chemical design of both a GSH-sensitive dimeric drug guest and glucose-derived nanocarrier host to achieve enhanced osteosarcoma lung metastatic anticancer selectivity”, Am. Chem. Soc., 2018, 140(4), 1438-1446, DOI:  10.1021/jacs.7b11462.
  • Tsao, Y.-Y.; Smith, T. H.; Wooley, K. L. “Regioisomeric Preference in Ring-opening Polymerization of 3’,5’ Cyclic Phosphoesters of Functional Thymidine DNA Analogues”, ACS Macro Lett., 2018, 7, 153-158, DOI:  10.1021/acsmacrolett.7b00858.
  • Zhang, F.; Khan, S.; Li, R.; Smolen, J. A.; Zhang, S.; Zhu, G.; Su, L.; Jahnke, A. A.; Elsabahy, M.; Chen, X.; Wooley, K. L. “Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading”, Nanoscale, 2017, 9, 15773-15777, DOI:  10.1039/C7NR05935C.
  • Fan, J.; Borguet, Y. P.; Su, L.; Nguyen, T. P.; Wang, H.; He, X.; Zou, J.; Wooley, K. L. “Two-dimensional Controlled Syntheses of Polypeptide Molecular Brushes via N-Carboxyanhydride Ring-opening Polymerization and Ring-opening Metathesis Polymerization”, ACS Macro Lett., 2017, 6, 1031-1035, DOI:  10.1021/acsmacrolett.7b00603. PMCID:  PMC5617330.
  • Su, L.; Heo, G. S.; Lin, Y.-N.; Dong, M.; Zhang, S.; Chen, Y.; Sun, G.; Wooley, K. L. “Syntheses of Triblock Bottlebrush Polymers through Sequential ROMPs:  Expanding the functionalities of molecular brushes”, Polym. Sci., Part A:  Polym. Chem., 2017, 55, 2966-2970, DOI:  10.1002/pola.28647 [A special issue in honor of Professor Robert H. Grubbs on the occasion of his 75th birthday].
  • Song, Y.; Chen, Y.; Su, L.; Li, R.; Letteri, R. A.; Wooley, K. L. “Crystallization-driven Assembly of Fully Degradable, Natural Product-based Poly(l-lactide)-block-poly(α-d-glucose carbonate)s in Aqueous Solution”, Polymer, 2017, 122, 270-279, DOI:  10.1016/j.polymer.2017.06.065 [A virtual special issue on “Advanced Polymer Synthesis for Functional Nanostructures” in honor of Axel H. E. Müller’s 70th birthday on May 8, 2017].
  • Lonnecker, A. T.; Lim, Y. H.; Wooley, K. L. “A Functional Polycarbonate of a d-Glucal-Derived Bicyclic Carbonate via Organocatalytic Ring-Opening Polymerization”, ACS Macro Lett., 2017, 6, 748-753, DOI:  10.1021/acsmacrolett.7b00362.
  • Fan, J.; Li, R.; Wang, H.; He, X.; Nguyen, T. P.; Letteri, R. A.; Zou, J.; Wooley, K. L. “Multi-responsive polypeptide hydrogels derived from N carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs)”, Biomol. Chem., 2017, 15, 5145-5154, DOI:  10.1039/C7OB00931C.
  • Tsao, Y.-Y.; Wooley, K. L. “Synthetic, Functional Thymidine-Derived Polydeoxyribonucleotide Analogues from a Six-Membered Cyclic Phosphoester”, Am. Chem. Soc., 2017, 139(15), 5467-5473, DOI:  10.1021/jacs.7b01116. PMCID:  PMC5451148.
  • Kristufek, S. L.; Wacker, K. T.; Tsao, Y.-Y.; Su, L.; Wooley, K. L. “Monomer design strategies to create natural product-based polymer materials”, Prod. Rep., 2017, 34, 433-459, DOI:  10.1039/c6np00112b.
  • N. K.; Hamad, M. A.; Hafez, M. Z. E.; Wooley, K. L.; Elsabahy M. “Nanomedicine in Management of Hepatocellular Carcinoma:  Challenges and Opportunities”, Int. J. Cancer, 2017, 140(7), 1475-1484, DOI:  10.1002/ijc.30517.
  • Su, L.; Khan, S.; Fan, J.; Lin, Y.-N.; Wang, H.; Gustafson, T. P.; Zhang, F.; Wooley, K. L. “Functional sugar-based polymers and nanostructures comprised of degradable poly(ᴅ-glucose carbonate)s”, Chem., 2017, 8, 1699-1707, DOI:  10.1039/C6PY01978A.
  • Wang, H.; Su, L.; Li, R.; Zhang, S.; Fan, J.; Zhang, F.; Nguyen, T. P.; Wooley, K. L. “Polyphosphoramidates that undergo acid-triggered backbone degradation”, ACS Macro Lett., 2017, 6, 219-223, DOI:  10.1021/acsmacrolett.6b00966.
  • Elzeny, H.; Zhang, F.; Ali, E. N.; Fathi, H. A.; Zhang, S.; Li, R.; El-Mokhtar, M. A.; Hamad, M. A.; Wooley, K. L.; Elsabahy, M. “Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA”, Drug Des. Devel. Ther., 2017, 11, 483-496, DOI:  10.2147/DDDT.S128503.
  • Zigmond, J. S.; Wooley, K. L. “Amphiphilic Crosslinked Liquid Crystalline Fluoropolymer-Poly(ethylene glycol) Coatings for Application in Challenging Conditions:  Comparative study between different liquid crystalline comonomers and polymer architectures”, ACS Appl. Mater. Interfaces, 2016 8(49), 33386-33393, DOI:  10.1021/acsami.6b11112.
  • Flores, J. A.; Jahnke, A. A.; Cheng, Z.; Wooley, K. L. “Magnetically-active Pickering Emulsions Stabilized by Hybrid Inorganic/Organic Networks”, Soft Matter, 2016, 12(46), 9342-9354, DOI:  10.1039/C6SM01830K.
  • Yang, G.; Kristufek, S. L.; Link, L. A.; Wooley, K. L.; Robertson, M. L. “Thiol-ene elastomers derived from biobased phenolic acids with varying functionality”, Macromolecules, 2016, 49(20), 7737-7748, DOI:  10.1021/acs.macromol.6b01018.
  • Lonnecker, A. T.; Lim, Y. H.; Felder, S. E.; Besset, C. J.; Wooley, K. L. “Four Different Regioisomeric Polycarbonates Derived from One Natural Product, ᴅ-Glucose”, Macromolecules, 2016, 49(20), 7857-7867, DOI:  10.1021/acs.macromol.6b00591.
  • Wacker, K. T.; Kristufek, S. L.; Lim, S.-M.; Kahn, S.; Wooley, K. L. “Bio-based Polycarbonates Derived from the Neolignan Honokiol”, RSC Advances, 2016, 6, 81672-81679, DOI:  10.1039/C6RA19568G.
  • Kristufek, S. L.; Yang, G.; Link, L. A.; Rohde, B. J.; Robertson, M. L.; Wooley, K. L. “Synthesis, Characterization and Cross-linking Strategy of a Quercetin-based Epoxidized Monomer as a Naturally-Derived Replacement for BPA in Epoxy Resins”, Sus. Chem., 2016, 9(16), 2135-2142, DOI:  10.1002/cssc.201600392.
  • Lim, Y. H.; Tiemann, K. M.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. “Polymeric Nanoparticles in Development for Treatment of Pulmonary Infectious Diseases”, Wiley Interdisciplinary Reviews (WIREs): Nanomed. Nanobiotechnol., 2016, 8(6), 842-871, DOI:  10.1002/wnan.1401. PMCID:  PMC5035710.
  • Zigmond, J. S.; Pavia-Sanders, A.; Russell, J. D.; Wooley, K. L. “Dynamic Anti-icing Coatings:  Complex, amphiphilic hyperbranched fluoropolymer poly(ethylene glycol) crosslinked networks with an integrated liquid crystalline comonomer”, Mater., 2016, 28(15), 5471-5479, DOI:  10.1021/acs.chemmater.6b02013.
  • He, X.; Fan, J.; Zou, J.; Wooley, K. L. “Reversible Photo-patterning of Soft Conductive Materials via Spatially-defined Supramolecular Assembly”, Commun., 2016, 52(54), 8455-8458, DOI: 10.1039/C6CC03579E. PMCID:  PMC5043637.
  • Zhao, Y.; Detering, L.; Sultan, D.; Cooper, M.; You, M.; Cho, S.; Meier, S.; Luehmann, H.; Sun, G.; Rettig, M.; Dehdashti, F.; Wooley, K. L.; DiPersio, J.; Liu, Y. “Gold Nanoclusters Doped with 64Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis”, ACS Nano, 2016, 10(6), 5959-5970, DOI:  10.1021/acsnano.6b01326.
  • Black, K. C.; Ibricevic, A.; Gunsten, S. P.; Flores, J. A.; Gustafson, T. P.; Raymond, J. E.; Samarajeewa, S.; Shrestha, R.; Felder, S. E.; Cai, T.; Shen, Y.; Lӧbs, A. K.; Zhegalova, N.; Sultan, D. H.; Berezin, M.; Wooley, K. L.; Liu, Y.; Brody, S. “In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging”, Biomaterials, 2016, 98, 53-63, DOI:  10.1016/j.biomaterials.2016.04.040. PMCID: PMC489910.
  • Kristufek, T. S.; Kristufek, S. L.; Link, L. A.; Weems, A. C.; Lonnecker, A. T.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Rapidly-cured Isosorbide Natural Product-based Cross-linked Polycarbonate Elastomers”, Chem., 2016, 7(15), 2639-2644, DOI:  10.1039/c5py01659b.
  • He, X.; Fan, J.; Wooley, K. L. “Stimuli-triggered Sol-Gel Transitions of Polypeptide Gels Derived from N-carboxyanhydride (NCA) Polymerizations”, Asian J., 2016, 11(4), 437–447, DOI:  10.1002/asia.201500957.
  • Zigmond, J. S.; Pollack, K. A.; Smedley, S.; Raymond, J. E.; Link, L. A.; Pavia-Sanders, A.; Hickner, M. A.; Wooley, K. L. “Investigation of Intricate, Amphiphilic Crosslinked Hyperbranched Fluoropolymers as Anti-icing Coatings for Extreme Environments”, Polym. Sci., Part A:  Polym. Chem., 2016, 54(2), 238–244, DOI:  10.1002/pola.27800.
  • Cho, S.; Heo, G. S.; Khan, S.; Gonzalez, A. M.; Elsabahy, M.; Wooley, K. L. “Functionalizable Hydrophilic Polycarbonate, Poly(5-methyl-5-(2-hydroxypropyl)aminocarbonyl-1,3-dioxan-2-one), Designed as a Degradable Alternative for PHPMA and PEG”, Macromolecules, 2015, 48(24), 8797–8805, DOI:  10.1021/acs.macromol.5b01974.
  • Yang, G.; Kristufek, S.; Link, L.; Wooley, K. L.; Robertson, M. “Synthesis and Physical Properties of Thiol-Ene Networks Utilizing Plant-Derived Phenolic Acids”, Macromolecules, 2015, 48(23), 8418-8427, DOI:  10.1021/acs.macromol.5b01796.
  • Yang, F.; Cho, S.; Sun, G.; Verkhoturov, S. V.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L.; Schweikert, E. A. “Nanodomain Analysis with Cluster-SIMS: Application to the characterization of macromolecular brush architecture”, Surface and Interface Analysis, 2015, 47(11), 1051-1055, DOI: 10.1002/sia.5812.
  • Elsabahy, M.; Heo, G. S.; Lim, S.-M.; Sun, G.; Wooley, K. L. “Polymeric Nanostructures for Imaging and Therapy”, Chem. Rev., 2015, 115, 10967-11011, DOI: 10.1021/acs.chemrev.5b00135.
  • Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48(16), 5621-5631, DOI: 10.1021/acs.macromol.5b00752.
  • Wagers, P. O.; Tiemann, K. M.; Shelton, K. L.; Kofron, W. G.; Panzner, M. J.; Wooley, K. L.; Youngs, W. J.; Hunstad, D. A. “Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model”, Antimicrobial Agents and Chemotherapy, 2015, 59(9), 5494-5502, DOI: 10.1128/AAC.00881-15.
  • Weems, A. C.; Raymond, J. E.; Wacker, K. T.; Gustafson, T. P.; Keller, B.; Wooley, K. L.; Maitland, D. J. “Examination of radio-opacity enhancing additives in shape memory polyurethane foams”, J. Appl. Polym. Sci., 2015, 132(33), 42054 (9 pp), DOI: 10.1002/app.42054.
  • Hearon, K.; Wierzbicki, M. A.; Nash, L. D.; Landsman, T. L.; Laramy, C.; Lonnecker, A. T.; Gibbons, M. C.; Ur, S.; Cardinal, K. O.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Processable Shape Memory Polymer System for Biomedical Applications”, Adv. Healthcare Mater., 2015, 4, 1386-1398, DOI: 10.1002/adhm.201500156.
  • Aweda, T. A.; Zhang, S.; Mupanomunda, C.; Burkemper, J.; Heo, G. S.; Bandara, N.; Lin, M.; Cutler, C. S.; Cannon, C. L.; Youngs, W. J.; Wooley, K. L.; Lapi, S. E. “Investigating the pharmacokinectics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer”, J. Labelled Comp. Radiopharm., 2015, 58(6), 234-241, DOI: 10.1002/jlcr.3289. PMCID: PMC4457551.
  • Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett., 2015, 4(6), 645-650, DOI: 10.1021/acsmacrolett.5b00227. PMCID:  PMC4477896.
  • Elsabahy, M.; Wooley, K. L. “Data Mining as a Guide for the Construction of Biocompatible Nanoparticles via Controlling Polymer Chemistry and Supramolecular Assembly”, Acc. Chem. Res., 2015, 48(6), 1620-1630, DOI: 10.1021/acs.accounts.5b00066. PMCID:  PMC4500541.
  • Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”, Chem. Mater., 2015, 27, 3775-3782, DOI: 10.1021/acs.chemmater.5b01523.
  • Seetho, K.; Zhang, S.; Pollack, K. A.; Zou, J.; Raymond, J. E.; Wooley, K. L. “Facile Synthesis of a Phosphorylcholine-based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings”, ACS Macro Lett., 2015, 4, 505-510, DOI: 10.1021/mz500818c.