Karen L. Wooley

Distinguished Professor - Chemistry

W.T. Doherty-Welch Foundation Chair in Chemistry

Presidential Impact Fellow

Contact Information

Phone: (979) 845-4077

Fax: (979) 862-1137

E-mail: wooley@mail.chem.tamu.edu

Departmental Page

Education

  • 1993    Ph. D. Cornell University, Polymer/Organic Chemistry.
  • 1988    B.S. Chemistry, Oregon State University.

Research Interests

Organic and polymer synthesis; novel macromolecular nanostructures for biomedical and materials applications; degradable polymers; nanoscale polymer assemblies; functional polymers; polymer modification.

Experience

  • 2009 – Present           W. T. Doherty-Welch Chair in Chemistry; Professor of Chemistry; Professor of Chemical Engineering, Texas A&M University
  • 2007 – 2009                Professor, Washington University, School of Medicine, Department of Radiology
  • 2006-2009                   James S. McDonnell Distinguished University Professor of Arts & Sciences
  • 1999-2009                   Professor, Washington University, School of Arts & Sciences, Department of Chemistry
  • 1996 – 2005                Faculty member in the Division of Biological and Biomedical Sciences, Chemical Biology Program, Washington University
  • 1993 – 1999                Assistant Professor, Department of Chemistry, Washington University

Patents

  • “Degradable Polycarbonate Sport Fishing Materials”, Wooley, Karen L.; Felder, Simcha E.; Versaw, Brooke A.; Jahnke, Ashlee A.; Link, Lauren A.; Wooley, Mark W.; Hinton, Charles A.; Howell, Jr., William R.; U.S. Provisional Patent Application Serial No. 62/362,885, filed July 15, 2016; U.S. Patent Application Serial No. 15/650,244, filed July 14, 2017; PCT International Application Serial No. PCT/US2017/042061, filed July 14, 2017.
  • “Functional, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy”, Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; U.S. Patent Application Serial No. 13/697,149, filed November 17, 2011; WO 2011143524, filed November 17, 2011; PCT International Application Serial No. PCT/US2011/036392, filed December 13, 2012; Prior Publication Data: US 2013/0137976 A1, May 30, 2013; U.S. Patent Number 9,295,650, issued March 29, 2016.
  • “Ternary Antifouling Compositions and Methods”, Wooley, Karen L.; Raymond, Jeffery E.; Pollack, Kevin A; Imbesi, Philip M; ; U.S. Patent Application Serial No. 14/575,625, filed December 18, 2014; WO 2013192529; Prior Publication Data: US 2015/0307720 A1, October 29, 2015; U.S. Patent Number 9,422,433 issued August 23, 2016.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,371, filed September 6, 2013; Prior Publication Data: US 2015/0072292 A1, March 12, 2015; U.S. Patent Number 9,405,189 issued August 2, 2016.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,343, filed September 6, 2013; Prior Publication Data: US 2015/0072291, filed March 12, 2015.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,019, filed November 19, 2012; Prior Publication Data: US 2014/0141376 A1, May 22, 2014; U.S. Patent Number 8,822,130 issued September 2, 2014.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,026, filed November 19, 2012; Prior Publication Data: US 2014/0141375 A1, May 22, 2014; U.S. Patent Number 9,223,214 issued December 29, 2015.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; Full Appl. Serial Number 13/681,012, filed November 19, 2012; Prior Publication Data: US 2014/0142252, May 22, 2014.
  • “Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same”, Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,002, filed November 19, 2012; Prior Publication Data: US 2014/0142249 A1, May 22, 2014; U.S. Patent Number 9,447,220 issued September 20, 2016.
  • “Polymer-Drug Systems”, Wooley, Karen L.; Zou, Jiong; El Sabahy, Mahmoud; Zhang, Shiyi; Zhang, Fuwu; U.S. Patent Number 9,545,447 issued January 17, 2017.
  • Brush Copolymers", Cheng, Chong; Khoshdel, Ezat; Wooley, Karen L.; Patent WO 2008/064972, US Patent 7,960,479 issued June 14, 2011.
  • "Functionalized, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy", Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; Appl. Serial Number 61/334,698; PCT Int. Appl. US11/36392; Filed May 15, 2011.
  • "Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH", Wooley, Karen L.; Dorshow, Richard B.; Freskos, John N.; Neumann, William L.; Shieh, Jeng J.; Lee, Nam S.; Lin, Yun; Sun, Guorong; Appl. Serial Number 61/334,723; PCT Int. Appl. US11/36411; Filed May 13, 2011.
  • "Degradable Polycarbonates From Polyhydroxy Natural Products", Wooley, Karen L; Besset, Celine J.; Lonnecker, Alexander T; Streff, Jennifer M.; Kristufek, Samantha L.; Hearon, Michael K.; Provisional; Appl. Serial Number 61/392,893; PCT/US2011/56204; Filed October 13, 2010.
  • "Composition Comprising Brush Copolymer For Treating Hair", Burry, Jason Shaun; Cheng, Chong; Evans, Richard Livesey; Khoshdel, Ezat; Wooley, Karen Lynn; Patent WO 2008/064973; granted August 2010.

Publications

Published— 

  • Su, L.; Li, R.; Khan, S.; Clanton, R.; Zhang, F.; Lin, Y.-N.; Song, Y.; Wang, H.; Fan, J.; Hernandez, S.; Butters, A. S.; Akabani, G.; MacLoughlin, R.; Smolen, J.; Wooley, K. L. “Chemical design of both a GSH-sensitive dimeric drug guest and glucose-derived nanocarrier host to achieve enhanced osteosarcoma lung metastatic anticancer selectivity”, Am. Chem. Soc., 2018, 140(4), 1438-1446, DOI:  10.1021/jacs.7b11462.
  • Tsao, Y.-Y.; Smith, T. H.; Wooley, K. L. “Regioisomeric Preference in Ring-opening Polymerization of 3’,5’ Cyclic Phosphoesters of Functional Thymidine DNA Analogues”, ACS Macro Lett., 2018, 7, 153-158, DOI:  10.1021/acsmacrolett.7b00858.
  • Zhang, F.; Khan, S.; Li, R.; Smolen, J. A.; Zhang, S.; Zhu, G.; Su, L.; Jahnke, A. A.; Elsabahy, M.; Chen, X.; Wooley, K. L. “Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading”, Nanoscale, 2017, 9, 15773-15777, DOI:  10.1039/C7NR05935C.
  • Fan, J.; Borguet, Y. P.; Su, L.; Nguyen, T. P.; Wang, H.; He, X.; Zou, J.; Wooley, K. L. “Two-dimensional Controlled Syntheses of Polypeptide Molecular Brushes via N-Carboxyanhydride Ring-opening Polymerization and Ring-opening Metathesis Polymerization”, ACS Macro Lett., 2017, 6, 1031-1035, DOI:  10.1021/acsmacrolett.7b00603. PMCID:  PMC5617330.
  • Su, L.; Heo, G. S.; Lin, Y.-N.; Dong, M.; Zhang, S.; Chen, Y.; Sun, G.; Wooley, K. L. “Syntheses of Triblock Bottlebrush Polymers through Sequential ROMPs:  Expanding the functionalities of molecular brushes”, Polym. Sci., Part A:  Polym. Chem., 2017, 55, 2966-2970, DOI:  10.1002/pola.28647 [A special issue in honor of Professor Robert H. Grubbs on the occasion of his 75th birthday].
  • Song, Y.; Chen, Y.; Su, L.; Li, R.; Letteri, R. A.; Wooley, K. L. “Crystallization-driven Assembly of Fully Degradable, Natural Product-based Poly(l-lactide)-block-poly(α-d-glucose carbonate)s in Aqueous Solution”, Polymer, 2017, 122, 270-279, DOI:  10.1016/j.polymer.2017.06.065 [A virtual special issue on “Advanced Polymer Synthesis for Functional Nanostructures” in honor of Axel H. E. Müller’s 70th birthday on May 8, 2017].
  • Lonnecker, A. T.; Lim, Y. H.; Wooley, K. L. “A Functional Polycarbonate of a d-Glucal-Derived Bicyclic Carbonate via Organocatalytic Ring-Opening Polymerization”, ACS Macro Lett., 2017, 6, 748-753, DOI:  10.1021/acsmacrolett.7b00362.
  • Fan, J.; Li, R.; Wang, H.; He, X.; Nguyen, T. P.; Letteri, R. A.; Zou, J.; Wooley, K. L. “Multi-responsive polypeptide hydrogels derived from N carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs)”, Biomol. Chem., 2017, 15, 5145-5154, DOI:  10.1039/C7OB00931C.
  • Tsao, Y.-Y.; Wooley, K. L. “Synthetic, Functional Thymidine-Derived Polydeoxyribonucleotide Analogues from a Six-Membered Cyclic Phosphoester”, Am. Chem. Soc., 2017, 139(15), 5467-5473, DOI:  10.1021/jacs.7b01116. PMCID:  PMC5451148.
  • Kristufek, S. L.; Wacker, K. T.; Tsao, Y.-Y.; Su, L.; Wooley, K. L. “Monomer design strategies to create natural product-based polymer materials”, Prod. Rep., 2017, 34, 433-459, DOI:  10.1039/c6np00112b.
  • N. K.; Hamad, M. A.; Hafez, M. Z. E.; Wooley, K. L.; Elsabahy M. “Nanomedicine in Management of Hepatocellular Carcinoma:  Challenges and Opportunities”, Int. J. Cancer, 2017, 140(7), 1475-1484, DOI:  10.1002/ijc.30517.
  • Su, L.; Khan, S.; Fan, J.; Lin, Y.-N.; Wang, H.; Gustafson, T. P.; Zhang, F.; Wooley, K. L. “Functional sugar-based polymers and nanostructures comprised of degradable poly(ᴅ-glucose carbonate)s”, Chem., 2017, 8, 1699-1707, DOI:  10.1039/C6PY01978A.
  • Wang, H.; Su, L.; Li, R.; Zhang, S.; Fan, J.; Zhang, F.; Nguyen, T. P.; Wooley, K. L. “Polyphosphoramidates that undergo acid-triggered backbone degradation”, ACS Macro Lett., 2017, 6, 219-223, DOI:  10.1021/acsmacrolett.6b00966.
  • Elzeny, H.; Zhang, F.; Ali, E. N.; Fathi, H. A.; Zhang, S.; Li, R.; El-Mokhtar, M. A.; Hamad, M. A.; Wooley, K. L.; Elsabahy, M. “Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA”, Drug Des. Devel. Ther., 2017, 11, 483-496, DOI:  10.2147/DDDT.S128503.
  • Zigmond, J. S.; Wooley, K. L. “Amphiphilic Crosslinked Liquid Crystalline Fluoropolymer-Poly(ethylene glycol) Coatings for Application in Challenging Conditions:  Comparative study between different liquid crystalline comonomers and polymer architectures”, ACS Appl. Mater. Interfaces, 2016 8(49), 33386-33393, DOI:  10.1021/acsami.6b11112.
  • Flores, J. A.; Jahnke, A. A.; Cheng, Z.; Wooley, K. L. “Magnetically-active Pickering Emulsions Stabilized by Hybrid Inorganic/Organic Networks”, Soft Matter, 2016, 12(46), 9342-9354, DOI:  10.1039/C6SM01830K.
  • Yang, G.; Kristufek, S. L.; Link, L. A.; Wooley, K. L.; Robertson, M. L. “Thiol-ene elastomers derived from biobased phenolic acids with varying functionality”, Macromolecules, 2016, 49(20), 7737-7748, DOI:  10.1021/acs.macromol.6b01018.
  • Lonnecker, A. T.; Lim, Y. H.; Felder, S. E.; Besset, C. J.; Wooley, K. L. “Four Different Regioisomeric Polycarbonates Derived from One Natural Product, ᴅ-Glucose”, Macromolecules, 2016, 49(20), 7857-7867, DOI:  10.1021/acs.macromol.6b00591.
  • Wacker, K. T.; Kristufek, S. L.; Lim, S.-M.; Kahn, S.; Wooley, K. L. “Bio-based Polycarbonates Derived from the Neolignan Honokiol”, RSC Advances, 2016, 6, 81672-81679, DOI:  10.1039/C6RA19568G.
  • Kristufek, S. L.; Yang, G.; Link, L. A.; Rohde, B. J.; Robertson, M. L.; Wooley, K. L. “Synthesis, Characterization and Cross-linking Strategy of a Quercetin-based Epoxidized Monomer as a Naturally-Derived Replacement for BPA in Epoxy Resins”, Sus. Chem., 2016, 9(16), 2135-2142, DOI:  10.1002/cssc.201600392.
  • Lim, Y. H.; Tiemann, K. M.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. “Polymeric Nanoparticles in Development for Treatment of Pulmonary Infectious Diseases”, Wiley Interdisciplinary Reviews (WIREs): Nanomed. Nanobiotechnol., 2016, 8(6), 842-871, DOI:  10.1002/wnan.1401. PMCID:  PMC5035710.
  • Zigmond, J. S.; Pavia-Sanders, A.; Russell, J. D.; Wooley, K. L. “Dynamic Anti-icing Coatings:  Complex, amphiphilic hyperbranched fluoropolymer poly(ethylene glycol) crosslinked networks with an integrated liquid crystalline comonomer”, Mater., 2016, 28(15), 5471-5479, DOI:  10.1021/acs.chemmater.6b02013.
  • He, X.; Fan, J.; Zou, J.; Wooley, K. L. “Reversible Photo-patterning of Soft Conductive Materials via Spatially-defined Supramolecular Assembly”, Commun., 2016, 52(54), 8455-8458, DOI: 10.1039/C6CC03579E. PMCID:  PMC5043637.
  • Zhao, Y.; Detering, L.; Sultan, D.; Cooper, M.; You, M.; Cho, S.; Meier, S.; Luehmann, H.; Sun, G.; Rettig, M.; Dehdashti, F.; Wooley, K. L.; DiPersio, J.; Liu, Y. “Gold Nanoclusters Doped with 64Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis”, ACS Nano, 2016, 10(6), 5959-5970, DOI:  10.1021/acsnano.6b01326.
  • Black, K. C.; Ibricevic, A.; Gunsten, S. P.; Flores, J. A.; Gustafson, T. P.; Raymond, J. E.; Samarajeewa, S.; Shrestha, R.; Felder, S. E.; Cai, T.; Shen, Y.; Lӧbs, A. K.; Zhegalova, N.; Sultan, D. H.; Berezin, M.; Wooley, K. L.; Liu, Y.; Brody, S. “In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging”, Biomaterials, 2016, 98, 53-63, DOI:  10.1016/j.biomaterials.2016.04.040. PMCID: PMC489910.
  • Kristufek, T. S.; Kristufek, S. L.; Link, L. A.; Weems, A. C.; Lonnecker, A. T.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Rapidly-cured Isosorbide Natural Product-based Cross-linked Polycarbonate Elastomers”, Chem., 2016, 7(15), 2639-2644, DOI:  10.1039/c5py01659b.
  • He, X.; Fan, J.; Wooley, K. L. “Stimuli-triggered Sol-Gel Transitions of Polypeptide Gels Derived from N-carboxyanhydride (NCA) Polymerizations”, Asian J., 2016, 11(4), 437–447, DOI:  10.1002/asia.201500957.
  • Zigmond, J. S.; Pollack, K. A.; Smedley, S.; Raymond, J. E.; Link, L. A.; Pavia-Sanders, A.; Hickner, M. A.; Wooley, K. L. “Investigation of Intricate, Amphiphilic Crosslinked Hyperbranched Fluoropolymers as Anti-icing Coatings for Extreme Environments”, Polym. Sci., Part A:  Polym. Chem., 2016, 54(2), 238–244, DOI:  10.1002/pola.27800.
  • Cho, S.; Heo, G. S.; Khan, S.; Gonzalez, A. M.; Elsabahy, M.; Wooley, K. L. “Functionalizable Hydrophilic Polycarbonate, Poly(5-methyl-5-(2-hydroxypropyl)aminocarbonyl-1,3-dioxan-2-one), Designed as a Degradable Alternative for PHPMA and PEG”, Macromolecules201548(24), 8797–8805, DOI:  10.1021/acs.macromol.5b01974.
  • Yang, G.; Kristufek, S.; Link, L.; Wooley, K. L.; Robertson, M. “Synthesis and Physical Properties of Thiol-Ene Networks Utilizing Plant-Derived Phenolic Acids”, Macromolecules, 2015, 48(23), 8418-8427, DOI:  10.1021/acs.macromol.5b01796.
  • Yang, F.; Cho, S.; Sun, G.; Verkhoturov, S. V.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L.; Schweikert, E. A. “Nanodomain Analysis with Cluster-SIMS: Application to the characterization of macromolecular brush architecture”, Surface and Interface Analysis, 2015, 47(11), 1051-1055, DOI: 10.1002/sia.5812.
  • Elsabahy, M.; Heo, G. S.; Lim, S.-M.; Sun, G.; Wooley, K. L. “Polymeric Nanostructures for Imaging and Therapy”, Chem. Rev., 2015, 115, 10967-11011, DOI: 10.1021/acs.chemrev.5b00135.
  • Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48(16), 5621-5631, DOI: 10.1021/acs.macromol.5b00752.
  • Wagers, P. O.; Tiemann, K. M.; Shelton, K. L.; Kofron, W. G.; Panzner, M. J.; Wooley, K. L.; Youngs, W. J.; Hunstad, D. A. “Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model”, Antimicrobial Agents and Chemotherapy, 2015, 59(9), 5494-5502, DOI: 10.1128/AAC.00881-15.
  • Weems, A. C.; Raymond, J. E.; Wacker, K. T.; Gustafson, T. P.; Keller, B.; Wooley, K. L.; Maitland, D. J. “Examination of radio-opacity enhancing additives in shape memory polyurethane foams”, J. Appl. Polym. Sci., 2015, 132(33), 42054 (9 pp), DOI: 10.1002/app.42054.
  • Hearon, K.; Wierzbicki, M. A.; Nash, L. D.; Landsman, T. L.; Laramy, C.; Lonnecker, A. T.; Gibbons, M. C.; Ur, S.; Cardinal, K. O.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Processable Shape Memory Polymer System for Biomedical Applications”, Adv. Healthcare Mater., 2015, 4, 1386-1398, DOI: 10.1002/adhm.201500156.
  • Aweda, T. A.; Zhang, S.; Mupanomunda, C.; Burkemper, J.; Heo, G. S.; Bandara, N.; Lin, M.; Cutler, C. S.; Cannon, C. L.; Youngs, W. J.; Wooley, K. L.; Lapi, S. E. “Investigating the pharmacokinectics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer”, J. Labelled Comp. Radiopharm., 2015, 58(6), 234-241, DOI: 10.1002/jlcr.3289. PMCID: PMC4457551.
  • Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett., 2015, 4(6), 645-650, DOI: 10.1021/acsmacrolett.5b00227. PMCID:  PMC4477896.
  • Elsabahy, M.; Wooley, K. L. “Data Mining as a Guide for the Construction of Biocompatible Nanoparticles via Controlling Polymer Chemistry and Supramolecular Assembly”, Acc. Chem. Res., 2015, 48(6), 1620-1630, DOI: 10.1021/acs.accounts.5b00066. PMCID:  PMC4500541.
  • Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”, Chem. Mater., 2015, 27, 3775-3782, DOI: 10.1021/acs.chemmater.5b01523.
  • Seetho, K.; Zhang, S.; Pollack, K. A.; Zou, J.; Raymond, J. E.; Wooley, K. L. “Facile Synthesis of a Phosphorylcholine-based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings”, ACS Macro Lett., 2015, 4, 505-510, DOI: 10.1021/mz500818c.