Quentin Michaudel

Associate Professor, Chemistry

Contact Information

Phone: (979) 458-2079

E-mail: quentin.michaudel@chem.tamu.edu

Department Website
Research Website
Web of Science Profile

Education

  • B.S., 2008, Ecole Normale Supérieure de Lyon
  • M.S., 2010, Ecole Normale Supérieure de Lyon
  • Ph.D., 2015, The Scripps Research Institute
  • Postdoctoral Fellow, 2015–2018, Cornell University

Research Interests

The focus of our group lies at the interface of organic chemistry, catalysis, and polymer science. We are interested in the development of reactions— including novel catalytic processes and polymerizations—allowing the synthesis of complex macro(molecule)s with unprecedented properties for applications ranging from energy production (e.g. solar cells), to sustainable plastics and novel therapeutics. Some key questions at the heart of our projects include: How does stereochemistry influence polymer properties and how can we harness it to design soft materials with tailored properties? Can we invent modular, efficient, and practical click reactions that afford functional and easily modifiable molecules?

Below are a few examples of projects that are actively being explored in the Michaudel Lab:

  1. The development of stereoselective olefin metathesis polymerizations for the precise synthesis of alkene-containing polymers
  2. The invention of SuFEx click processes coupled with photochemistry and catalysis to rapidly synthesize and functionalize both small molecules and polymers
  3. The use of heteroaryne chemistry to access nitrogenated polymers with tunable structures

Through monomer, catalyst, and polymer preparation, researchers will receive extensive training in the fields of synthetic organic chemistry, as well as polymer synthesis and characterization.

Publications

  • 26) Doktor, K.; Vantourout J. C.;* Michaudel, Q.* A Unified Synthesis of Diazenes from Primary Amines Using a SuFEx/Electrochemistry Strategy. Org. Lett. 2024, 26, 7501–7506.
  • 25) Mandal, H.; Ogunyemi, O.; Nicholson, J. L. Orr, M.; Lalisse, R. F.; Rentería-Gómez, Á; Gogoi, A. R.; Gutierrez, O.; Michaudel, Q.;* Goodson, T.* Linear and Nonlinear Optical Properties of all-cis and all-trans Poly(p-phenylene vinylene). J. Phys. Chem. C 2024, 128, 2518–2528.
  • 24) Hancock, S. N. Yuntawattana, N.; Diep, E.; Maity, A.; Tran, A.; Schiffman. J.;* Michaudel, Q.* Ring-opening Metathesis Polymerization of N-methylpyridinium-fused Norbornenes to Access Antibacterial Main-chain Cationic Polymers. Proc. Natl. Acad. Sci. 2023, 120, e2311396120.
  • 23) Wu, Z.; Wu, J. W.; Michaudel, Q.;* Jayaraman, A.* Design of Polysulfamide Self-assembly Aided by Molecular Modeling and Simulations. Macromolecules 2023, 56, 5033–5049.
  • 22) Kempel, S. J.;† Hsu, T.-W.;† Nicholson, J. N.; Michaudel, Q.* cis-Selective Acyclic Diene Metathesis Polymerization of α,ω-Dienes. J. Am. Chem. Soc. 2023, 145, 12459–12464.
  • 21) Chattapadhyay, D.;† Aydogan, A.;† Doktor, K.; Maity, A.; Wu, J. W.; Michaudel, Q.* Harnessing Sulfur(VI) Fluoride Exchange Click Chemistry and Photocatalysis for Deaminative Benzylic Arylation. ACS Catal. 2023, 13, 7263–7268.
  • 20) Wu, J. W.; Kulow, R. W.; Redding, M. J.; Fine, A. J.; Grayson, S. M.; Michaudel, Q.* Synthesis of Degradable Polysulfamides via Sulfur(VI) Fluoride Exchange Click Polymerization of AB-type Monomers. ACS Polym. Au. 2023, 3, 259–266. Invited contribution to the “2023 Rising Stars collection.”
  • 19) Hsu, T.-W.;† Kempel, S. J.;† Felix Thayne, A. P.; Michaudel, Q.* Stereocontrolled Acyclic Diene Metathesis Polymerization. Nat. Chem. 2023, 15, 14–20.
  • 18) Hancock, S.;† Yuntawattana, N.;† Valdez, S.; Michaudel, Q.* Expedient Synthesis and Ring-Opening Metathesis Polymerization of Pyridinonorbornenes. Polym. Chem. 2022, 13, 5530–5535. Invited contribution to “Polymer Chemistry Emerging Investigators Series.”
  • 17) Michaudel, Q.;* Kempel, S. J.; Hsu, T.-W.; deGruyter, J. N. E vs Z Selectivity in Olefin Metathesis Through Catalyst Design. In Comprehensive Organometallic Chemistry IV, 4th Quentin Michaudel, C.V., September 2024 3 ed.; Parkin, G. F. R.; Meyer, K.; O'Hare, D. Eds; Kidlington, UK: Elsevier, 2022, 265–338.
  • 16) Hsu, T.-W.; Kempel, S. J.; Michaudel, Q.* All-cis Poly(p-phenylene vinylene)s with High Molar Masses and Fast Photoisomerization Rates Obtained through Stereoretentive Ring- opening Metathesis Polymerization of [2,2]Paracyclophane Dienes with Various Aryl Substituents. J. Polym. Sci. 2022, 60, 569–578.
  • 15) Sousa e Silva, F. C.; † Doktor, K.; † Michaudel, Q.* Modular Synthesis of Alkenyl Sulfamates and β-Ketosulfonamides via Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry and Photomediated 1,3-Rearrangement. Org. Lett. 2021, 23, 5271–5276.
  • 14) Kempel, S. J.; Hsu, T.-W.; Michaudel, Q.* Stereoretentive Olefin Metathesis: A New Avenue for the Synthesis of All-cis Poly(p-phenylene vinylene)s and Stereodefined Polyalkenamers. Synlett 2021, 32, 851–857.
  • 13) Kulow, R. W.;† Wu, J. W.;† Kim, C.; Michaudel, Q.* Synthesis of Unsymmetrical Sulfamides and Polysulfamides via SuFEx Click Chemistry. Chem. Sci. 2020, 11, 7807– 7812.
  • 12) Hsu, T.-W.;† Kim, C.;† Michaudel, Q.* Stereoretentive Ring-Opening Metathesis Polymerization to Access All-cis Poly(p-phenylenevinylene)s with Living Characteristics. J. Am. Chem. Soc. 2020, 142, 11983–11987.
  • 11) Kottisch, V.; O’Leary, J.; Michaudel, Q.; Stache, E. E.; Lambert, T. H.; Fors, B. P. Controlled Cationic Polymerization: Single-Component Initiation Under Ambient Conditions. J. Am. Chem. Soc. 2019, 141, 10605–10609.
  • 10) Michaudel, Q.; Chauviré, T.; Kottisch, V.; Supej, M. J.; Stawiasz, K. J.; Shen, L.; Zipfel, W. R.; Abruña, H. D.; Freed, J. H.; Fors, B. P. Mechanistic Insight into the Photocontrolled ationic Polymerization of Vinyl Ethers. J. Am. Chem. Soc. 2017, 139, 15530–15538.
  • 9) Kottisch, V.; Michaudel, Q.; Fors, B. P. Photocontrolled Interconversion of Cationic and Radical Polymerizations. J. Am. Chem. Soc. 2017, 139, 10665–10668.
  • 8) Trotta, J. T.; Jin, M.; Stawiasz, K. J.; Michaudel, Q.; Chen, W.-L.; Fors, B. P. Synthesis of Methylene Butyrolactone Polymers from Itaconic Acid. J. Polym. Sci. Part A: Polym. Chem. 2017, 55, 2730–2737.
  • 7) Michaudel, Q.; Kottisch, V.; Fors, B. P. Cationic Polymerization: From Photoinitiation to Photocontrol. Angew. Chem. Int. Ed. 2017, 56, 9670–9679.
  • 6) Kottisch, V.;† Michaudel, Q.; † Fors, B. P. Cationic Polymerization of Vinyl Ethers Controlled by Visible Light. J. Am. Chem. Soc. 2016, 138, 15535–15538.
  • 5) Michaudel, Q.; Fors, B. P. Storing Information at the Molecular Level: Efficient Synthesis of “Barcode” Polymers. Chem 2016, 1, 23–24.
  • 4) Dao, H.; Li, C.;† Michaudel, Q.; † Maxwell, B. D.; Baran, P. S. Direct Hydromethylation of Unactivated Olefins. J. Am. Chem. Soc. 2015, 137, 8046–8049.
  • 3) Teufel, R.; Stull, F.; Meehan, M. J.; Michaudel, Q.; Dorrestein, P. C.; Palfey,B.; Moore, B. S. Biochemical Establishment and Characterization of EncM's Flavin-N5-Oxide Cofactor. J. Am. Chem. Soc. 2015, 137, 8078–8085.
  • 2) Shaw, S. A.; Balasubramanian, B.; Bonacorsi, S.; Caceres Cortes, J.; Cao, K.; Chen,B-C.; Dai,J.; Decicco, C.; Goswami, A.; Guo, Z.; Hanson,R.; Humphreys, W. G.; Lam, P. Y. S.; Li, W.; Mathur, A.; Maxwell, B. D.; Michaudel, Q.; Peng, L.; Pudzianowski, A.; Qiu, F.; Su, Quentin Michaudel, C.V., September 2024 4 S.; Sun, D.; Tymiak, A. A.; Vokits,B. P.; Wang,B.; Wexler, R.; Wu, D-R.; Zhang, Y.; Zhao, R.; Baran, P. S. Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development. J. Org. Chem. 2015, 80, 7019–7032.
  • 1) Michaudel, Q.; Ishihara, Y.; Baran, P.S. Academia−Industry Symbiosis in Organic Chemistry. Acc. Chem. Res. 2015, 48, 712–721.